The Health Emerging & Advanced Technologies Division (HEAT-D) has a goal to grow a forward-looking, comprehensive capability in health data exchange and analytics technologies that brings innovative, cross-disciplinary methods and emerging techniques to the laboratory’s diverse information science portfolio. Current efforts include a portfolio of projects in federal and state public health, industry and foundational sponsorships, and internally funded research that encompasses clinical phenotyping, natural language processing, machine learning, synthetic data generation and interoperability and security standards and protocols, among other technologies and applications, for data exchange between electronic health records and reporting systems. The corpus of work naturally encompasses crucial cybersecurity and privacy considerations or technologies to ensure data security, HIPAA rules, authentication and authorization protocols, and IRB privacy protocols for research datasets, among others. This work is integral to developing robust and scalable proof-of-concept solutions. The Health Interoperability & Security Branch (HIS-B) focuses on applying health interoperability and security solutions to integrating health data systems for a wide variety of projects in multiple domains, including clinical care, research, public health improvement, cost and quality, and consumer-based health applications.